INSCYTE Corporation

2 Berkeley Street, Suite 403,
Toronto, Ontario, Canada M5A 2W3
Tel: 416-594-9393
Fax: 416-594-2420

CytoBase Report
Cervical Cytology Database Statistics

April, 1999 through June 30, 1999

Newly Registered Women
Distribution of Report Diagnoses by Age and Class
Reports of ASCUS and AGUS
Reports of Low Grade and High Grade Lesions
Reports of Carcinoma and Other Malignancies

Newly Registered Women [Back to Top]

The following table describes the age distribution of women screened for the first time in the CytoBase system during the first quarter of 1999, and as an annualized2 percentage of the female population of the province of Ontario1. In this period, the system captured an annualized 6.19% of the female population.

The qualifying criteria for inclusion in this list are that 1) the patient’s specimen was collected during the time period in question and 2) this is the patient’s first report registered in the system. The criteria used in Volume 1 and 2 of the CytoBase reports were less stringent, counting all patients who were being registered in the database for the first time, regardless of the specimen date. Because of this, the figures appearing in Volume 1 and 2 are not comparable with those in Volume 3.

Age Group Number Registered Ontario Population1 % of cohort Registered (annualized)2
       
10-19 6,006 715,650 3.36%
20-29 15,568 803,100 7.75%
30-39 18,952 999,769 7.58%
40-49 16,502 845,361 7.81%
50-59 10,268 563,225 7.29%
60-69 6,090 463,166 5.26%
70+ 3,244 565,139 2.30%
       
Total 76,630 4,955,410 6.19%

1 Demography Division, Statistics Canada: preliminary postcensal estimates for 1996 Ontario population.
2 Percent of cohort registered is generated by dividing the number of women registered in the quarter by the Ontario population and then multiplying by four to obtain an estimate for the entire year.

Distribution of Report Diagnoses by Age and Class [Back to Top]

The following table lists reported findings categorized by a diagnostic class (most severe finding on the report) correlated by the woman's age as at the time of the test. The age is calculated based on the woman's date of birth relative to the date of specimen collection. Reports where age could not be determined are not included in the counts.

Age WNL BCC ASCUS AGUS LSIL HSIL Inv.Ca. Oth.Mal Oth.Ab Total %
                       
10-19 7,445 1,437 358 15 278 23 0 0 0 9,556 4.67%
20-29 35,542 6,849 1,683 205 1,039 230 0 0 3 45,551 22.26%
30-39 43,700 8,724 1,673 365 575 202 3 0 3 55,245 27.00%
40-49 33,957 7,623 1,454 355 305 107 1 0 0 43,802 21.41%
50-59 23,061 4,011 856 283 117 33 4 1 3 28,369 13.86%
60-69 13,087 1,752 358 98 55 15 2 0 1 15,368 7.51%
70+ 5,770 747 142 43 11 17 8 2 1 6,741 3.29%
                       
Total 162,562 31,143 6,524 1,364 2,380 627 18 3a 11b 204,632c 100.00%
% 79.44% 15.22% 3.19% 0.67% 1.16% 0.31% 0.01% 0.00% 0.01% 100.00%  

a INSCYTE will follow-up with the source laboratories for clarification of other malignancies.
b The "other abnormal" category includes findings and/or suspicion of abnormalities that were not formally classified.
c The total number of reports in the above table is less than the number of repors registered because in certain cases the age of the woman, or the diagnostic class cannot be determined from submitted information.

Reports of ASCUS and AGUS [Back to Top]

Atypical squamous cells of undetermined significance account for 3.19% (6,524) of reported findings.

Atypical glandular cells of undetermined significance account for 0.67% (1,364) of reported findings.

Reports of Low Grade and High Grade Lesions [Back to Top]

Low grade intraepithelial lesions account for 1.16% (2,380) of reported findings.

High grade intraepithelial lesions account for 0.31% (627) of reported findings.

Reports of Carcinoma and Other Malignancies [Back to Top]