INSCYTE Corporation

2 Berkeley Street, Suite 403,
Toronto, Ontario, Canada M5A 2W3
Tel: 416-594-9393
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CytoBase Report
Cervical Cytology Database Statistics

January 1, 1999 through December 31, 1999

Newly Women Registered
Distribution of Report Diagnoses by Age and Severity
Reports of Carcinoma and Other Malignancies
Reports of ASCUS and AGUS
Reports of Low Grade and High Grade Lesions
Specimen Adequacy

Women Registered: January 1, 1999 - December 31, 1999 [Back to Top]

The following table describes the age distribution of women registered for the first time in the CytoBase system during the calendar year 1999, and as a percentage of the female population of the province of Ontario. In this period, the system captured 11.05% of the female population.

The qualifying criteria for inclusion in this list are that 1) the patient’s specimen was collected during the time period in question and 2) this is the patient’s first report registered in the system. The criteria used in Volume 1 and 2 of the CytoBase reports were less stringent, counting all patients who were being registered in the database for the first time, regardless of the specimen date. Because of this, the figures appearing in Volume 1 and 2 are not comparable with those in Volume 3

Age Group Number Registered Ontario Population1 % of cohort Registered (annualized)
10-19 40,914 731,513 5.59%
20-29 124,742 776,867 16.06%
30-39 144,521 984,163 14.68%
40-49 117,012 876,454 13.35%
50-59 72,773 623,738 11.67%
60-69 40,127 464,609 8.64%
70-79 17,222 381,286 4.52%
80-89 2,560 170,089 1.51%
90+ 164 35,163 0.47%
Total 557,311 5,043,882 11.05%

1 Demography Division, Statistics Canada: preliminary post-census estimates for 1998 Ontario population.

Distribution of Report Diagnoses by Age and Class [Back to Top]

The following table lists reported findings categorized by diagnostic class (most severe finding on the report) and the woman’s age. The age is calculated based on the woman’s date of birth relative to the date of the specimen.

Age NAC BA ASCUS AGUS LGSIL HGSIL Inv.Ca. Oth.Mal1 Oth.Ab2 Total %
10-19 40,566 7,201 1,984 77 1,493 167 0 0 0 51,488 4.39%
20-29 212,642 35,184 9,669 967 5,772 1,591 4 0 19 265,848 22.67%
30-39 261,140 43,589 8,934 1,662 3,236 1,458 15 2 19 320,055 27.29%
40-49 201,431 37,820 7,630 1,751 1,733 733 20 3 11 251,131 21.41%
50-59 136,173 20,598 4,303 1,241 740 248 20 3 14 163,344 13.93%
60-69 72,477 8,440 7,727 426 251 114 17 4 5 83,461 7.12%
70-79 28,644 3,125 619 121 94 84 33 4 7 32,731 2.79%
80-89 3,830 482 80 26 16 10 10 0 2 4,456 0.38%
90+ 198 27 5 0 1 1 0 1 0 233 0.02%
Total 957,101 156,466 34,951 6,271 13,335 4,406 119 17 81 1,172,7473 100.00%
% 81.61% 13.34% 2.98% 0.53% 1.14% 0.38% 0.01% 0.00% 0.01% 100.00%

1 INSCYTE will follow-up with the source laboratories for clarification of other malignancies.
2 The "other abnormal" category includes findings and/or suspicion of abnormalities that were not formally classified.
3 The total number of reports in the above table is less than the number of reports registered because in certain cases the age of the woman, or the diagnostic class cannot be determined from submitted information.

Reports of ASCUS and AGUS [Back to Top]

Atypical squamous cells of undetermined significance account for 2.98% (34,951) of reported findings.

Atypical glandular cells of undetermined significance account for 0.53% (6,271) of reported findings.

Reports of Low Grade and High Grade Lesions [Back to Top]

Low grade intraepithelial lesions account for 1.14% (13,335) of reported findings.

High grade intraepithelial lesions account for 0.38% (4,406) of reported findings.

Reports of Carcinoma and Other Malignancies [Back to Top]

Specimen Adequacy [Back to Top]

Of all reports where specimen adequacy was reported (925,285), 0.75% of the specimens were deemed unsatisfactory for a cytological evaluation. The remaining 99.25% of the specimens were deemed satisfactory although some of these exhibited specific limitations as described below and on the following page.

Within the specimens which were adequate for cytological evaluation (918,300), 25.65% were limited in some way and 74.35% were without limitation.

Breakdown of Specimen Limitations

Total satisfactory & limited by specimens: 760,193 100.00%
Satisfactory: 682,781 74.35%
Limited by: absence of transformation zone material 118,251 15.56%
scant cellularity 11,363 1.24%
partial drying & degeneration 4,994 0.54%
obscuring inflammation 25,212 2.75%
obscuring blood 10,226 1.11%
excessive cytolosis 2,252 0.25%
other reasons 18,764 2.04%
lack of clinical data 6,026 0.66%
obscuring bacteria 1,573 0.17%
Total limited specimens: 235,519 25.65%

Reasons for Unsatisfactory Specimen

Total reports with specimen adequacy specified 925,285 100.00%
Unsatisfactory (no reason provided): 41 0.00%
Due to: obscuring blood 1,056 0.11%
obscuring inflammation 1,319 0.14%
acellularity 201 0.02%
insufficient cellular material 2,662 0.29%
excessive drying artifacts 73 0.01%
presence of endocervical cells only 1,390 0.15%
other reasons 140 0.02%
excessively thick preparation 44 0.00%
presence of foreign material 24 0.00%
broken slide 0 0.00%
obscuring bacteria 35 0.00%
Total unsatisfactory specimens: 6,985 0.75%

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